Tumor Suppressor Genes

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

Tumor suppressor genes.

Carcinogenesis is a multistep process in which cells accumulate multiple genetic alterations as they progress to a more malignant phenotype. Allelic chromosomal losses as well as mutations of tumor suppressor genes are common genetic events in the development and/or progression of both hereditary and non-hereditary tumors. Recent studies have shown a direct correlation between malignancy and in...

Tumor suppressor genes.

Epigenetics and Tumor Suppressor Genes

Oncogenes and tumor suppressor genes.

The genetic paradigm of cancer — that tumors arise as a consequence of the accumulation of mutations in genes controlling cell proliferation, differentiation or death — is now widely accepted. The purpose of this is lecture provide a review of current knowledge on the various types of cancer genes identified so far in different stages of tumor development. We will also address recent attempts t...